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LegitScript Certified Topical CBD
Professional-Grade Topical CBD for Hands on Practitioners
Your wholesale supplier of certified CBD topicals.
Pro Cream
Deep Tissue, Muscle, Back & Joint
5-Star User Rating
CBD: 2,000mg
CBD: 2,000mg
THC: 0.0%
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SKU: PC4K10
CBD Cooling Cream
Full Spectrum, Full Body Relief & Recovery
4.8-Star User Rating
CBD: 4,000mg
THC: < 0.3%
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SKU: PC4k10
Pro Roll-on
Max Power Muscle, Back & Joint
4.9-Star User Rating
CBD: 2,000mg
CBG: 2,000mg
THC: 0.0%
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SKU: PRO4K9
LegitScript Certified
100% U.S. Made
Quality & Saftey Guaranteed
Customer Reviews
"The most effective on the market! I’ve used several different CBD creams in my clinic and this one comes out on top by far. My patients will even request it! The best customer service too. Great company and great product."
Renee T.
Waltham Holistic Clinic
"Our patients love this product! We do too! As the person that receives the product, I appreciate the care in packing the boxes."
Dr. Eric P., D.C.
Fuhr Chiropractic Clinic
"Flying off the shelf! We love it, our patients love it! We're having a hard time keeping enough on hand!"
Dr. Rick S., DC
Activate Chiropractic
"My patients and I love this stuff!"
Lellani H. Acu
Jasmine Pearl Acupuncture
"Kannaco reached out and although I receive interest from many companies, my instincts led me to give them a shot, and they haven’t disappointed. I’ve tried many others and quite honestly, through patient feedback Kannaco has proved to be the best."
Dr. Tony W. D.A.O.M, PhD
Acupuncture Zen in Delray Beach, FL
"Being a compound pharmacy, our profession is working with patients and their primary care physicians to fit their specific needs. Kannaco has proven to be a valuable part of that equation as a relief option that my patients continue to come back for."
Dr. Rachel D., PharmD, R.P.
InnovativeRx in Kearney, NE
"The Kannaco Pro Roll-on is my go-to post treatment with patients. This is great for shoulders, neck and lower back. I love how quickly the product works. Not only for patient use but one of my favorites for personal use as well."
Dr. Sam W., D.C., ART, TPI
Fix Medical Group in San Diego, CA
"Excellent Product!. This is an amazingly effective CBD +CBG cream.
Dr. Debbie N., D.C.
Carlsbad, CA
Formulation Science: Topical CBD
How does topical CBD work?
CBD topicals work by interacting with your skin's receptor networks, sensory channels and lipid systems—supporting natural receptor balance, optimizing delivery through lipid emulsions.
Part 1
The Science Beneath the Surface
Our certified CBD formulations are engineered to work with your body’s natural systems — not against them. Our formulas interact with sensory pathways and lipid structures within the skin to promote balance, comfort, and overall wellness from the surface down.
Key Mechanisms
• Supports the skin’s natural endocannabinoid system (ECS) and receptor networks for local equilibrium
• Engages TRP channels that regulate temperature and sensory cues
• Lipid-based design enhances absorption through the skin’s barrier
Part 2
Smart Pathways, Intelligent Design
Beneath the surface, communication happens through complex receptor networks and cellular signals. Our topical CBD formulations are built to complement these systems, ensuring precision, efficiency, and lasting performance.
Key Mechanisms
• Interacts with CB1 and CB2 receptor sites found within skin and nerve endings
• Activates PPAR-α, a lipid metabolism pathways supporting renewal and resilience
• Utilizes microfluidized emulsions and reduced particle size for deep uniform delivery
Part 3
Advanced Delivery, Lasting Harmony
Our Adaptive Density Emulsion (ADE) blends ensure every ingredient works where it’s needed most, providing consistent results — balanced sensory feedback, superior glide, and skin that feels supported and restored long after application.
Key Mechanisms
• ADE system ensures even distribution and stability
• Balances sensory response through TRPM8 / TRPA1 modulation
• Helps maintain natural barrier integrity for smoother, healthier skin
FAQ: Topical CBD for Relief
How does topical CBD provide relief?
What happens when you apply a topical CBD cream to the skin?
When applied topically, cannabinoids like CBD and CBG interact with the skin’s Endocannabinoid System (ECS), a dense network of receptors, lipid layers, and sensory channels. Rather than entering the bloodstream, they remain localized—absorbing into skin and underlying tissue where they can influence cell signaling and support balance.
What are TRP channels and why do they matter?
TRP (Transient Receptor Potential) channels are tiny sensory “gateways” found on skin nerve endings and keratinocytes. They detect temperature and touch — for example:
TRPM8 responds to cooling sensations (menthol-like).
TRPA1 reacts to contrast and tingling.
TRPV1 senses warmth and pressure.
What are CB1 and CB2 receptors?
These are cellular receptor sites that respond to naturally occurring compounds in the body.
CB1 receptors are found mostly in nerve endings and keratinocytes.
CB2 receptors are located in immune and structural skin cells.
When engaged, they influence how the skin perceives and responds to environmental stressors.
Why is lipid-based delivery important for topical performance?
Because the skin is mostly made of lipids, formulations that use oil-in-water emulsions or microfluidized lipid carriers can mimic this structure. This improves both compatibility and diffusion, ensuring ingredients remain stable and effective where they’re needed most.
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