The Science of Topical Cannabinoids

Topical CBD and CBG: The Complete Professional Picture

A practitioner-level guide to full spectrum hemp extract, the entourage hypothesis, the difference between topical and transdermal, and how Kannaco formulations compare.

100+Phytocannabinoids in full spectrum
EntourageEffect: a research hypothesis
0.0%THC on batch COAs
SC LabsISO-accredited COA verification

Key Terminology

Definitions Every Practitioner Should Know

Plain definitions for the core terminology used in cannabinoid science and topical formulation, with practitioner-relevant context for each.

Full Spectrum Extract

An extract that retains all naturally occurring compounds from the hemp plant: cannabinoids, terpenes, flavonoids, and trace THC (below 0.3% by federal law). The full chemical profile is preserved.

Professional relevance

Preferred when the goal is the full phytochemical profile of the plant.

Broad Spectrum Extract

An extract that retains most hemp plant compounds but has had THC specifically removed through additional processing. THC is below detectable limits, which is not the same as a verified 0.0%.

Professional relevance

A middle option between full spectrum and isolate. Less common in topical formulations than either.

CBD Isolate

Pure cannabidiol in crystalline form, with all other compounds removed. 99%+ CBD by weight with 0.0% THC.

Professional relevance

The most precisely defined formulation option, with no THC content. Used in Kannaco Pro Cream and Pro Roll-On paired with CBG isolate.

CBG (Cannabigerol)

A non-psychoactive cannabinoid sometimes called the 'mother cannabinoid' because other cannabinoids are biosynthesized from its precursor form (CBGA).

Professional relevance

Kannaco Pro formulas pair CBG isolate with CBD isolate in a 1:1 ratio.

The Entourage Effect

A hypothesis, first proposed by Raphael Mechoulam, about how cannabinoids and terpenes behave together in a whole-plant extract. It remains a hypothesis.

Professional relevance

A term practitioners will hear alongside full spectrum extracts. Present it as a research hypothesis, not as a product benefit.

Endocannabinoid System (ECS)

A biological signaling system present in all mammals. It is a subject of ongoing research.

Professional relevance

Background term only. Kannaco topicals are applied to the skin, and we do not claim that they act on this system.

Terpenes and Flavonoids

Naturally occurring hemp compounds found alongside cannabinoids. Terpenes in hemp include beta-caryophyllene, linalool, and myrcene. Flavonoids include quercetin and kaempferol.

Professional relevance

These compounds are retained in a full spectrum extract and removed from an isolate.

Certificate of Analysis (COA)

A lab report for a specific batch. Kannaco COAs come from SC Labs (ISO/IEC 17025 accredited) and list cannabinoid content, including THC.

Professional relevance

The document to share when a client or staff member asks what is in a product. COAs are available on request for every batch.

Topical vs. Transdermal

A topical product is applied to the surface of the skin. Transdermal is a separate product category designed to move compounds through the skin.

Professional relevance

Use the word topical, not transdermal, when describing a cream or roll-on.

Background Concepts

Three Concepts Behind Full Spectrum Topicals

Three background concepts practitioners hear about full spectrum topicals, and how to describe them accurately to your clients and team.

The Endocannabinoid System: Background Only

The endocannabinoid system (ECS) is a signaling network found in all mammals, and researchers have also described it in the skin. It is an active field of study and a term your clients may bring up.

Kannaco topicals are applied to the skin, and we do not claim that they act on the ECS or change any body process. When the subject comes up, describe the products by what they are: a cream or roll-on applied to the skin, with a cooling or warming feel.

Practice note

Kannaco topicals are applied to the skin, and we do not claim that they treat, cure or prevent any condition.

The Entourage Effect: A Research Hypothesis

Full spectrum hemp extract contains over 100 identified phytocannabinoids alongside terpenes, flavonoids, and fatty acids. The entourage effect, first described by Raphael Mechoulam and Shimon Ben-Shabat in 1998, is a hypothesis about how these compounds behave together.

It remains a hypothesis. For a topical, the practical meaning of full spectrum is simple: the extract keeps the naturally occurring compounds of the plant, including trace THC, while an isolate contains only the selected cannabinoids.

Practice note

The entourage effect is a hypothesis. Do not present it to clients as a benefit of any Kannaco product.

Topical vs. Transdermal: Two Different Terms

Topical and transdermal are not interchangeable terms. A topical product is applied to the surface of the skin. Transdermal is a separate product category designed to move compounds through the skin.

All Kannaco products are topicals. They are applied to the skin and described by their feel, texture and ingredient list. For questions about drug testing, refer to the THC figure on each batch-specific Certificate of Analysis and never promise a test outcome.

Practice note

Use the word topical when you describe a Kannaco cream or roll-on to clients and staff.

Ingredient Science

Every Ingredient. Every Role.

A practitioner-level breakdown of the key cannabinoid, botanical and sensory ingredients across the Kannaco topical line, with the role of each.

Cannabinoid

CBD (Cannabidiol)

Primary cannabinoid in all three formulas

CBD (cannabidiol) is a cannabinoid from hemp. All three formulas pair CBD with CBG and contain 0.0% THC. Cannabinoid content for every batch is listed on its Certificate of Analysis.

Cooling CreamPro CreamPro Roll-On
Cannabinoid

CBG (Cannabigerol)

Second cannabinoid in all three formulas

CBG (cannabigerol) is a non-psychoactive cannabinoid. The Pro formulas pair CBG isolate with CBD isolate in a 1:1 ratio, with 0.0% THC. The Cooling Cream also pairs CBD with CBG, with 0.0% THC.

Cooling CreamPro CreamPro Roll-On
Botanical

Arnica Montana Flower Extract

Botanical extract in the aromatic blend

Arnica montana flower extract is a botanical ingredient that contains sesquiterpene lactones (helenalin, dihydrohelenalin). In Kannaco formulas it is part of the warming, aromatic botanical blend.

Cooling CreamPro Cream
Sensory

Menthol

Cooling feel on the skin

Menthol gives the characteristic cooling feel on the skin without an actual temperature change. The cooling onset in all three Kannaco formulas is primarily driven by menthol.

Cooling CreamPro CreamPro Roll-On
Sensory

Camphor

Warming feel, part of the aromatic blend

Camphor gives the warming feel that follows the menthol cooling phase. This sensory arc, a cooling onset followed by a warming mid-phase, is a hallmark of all three Kannaco formulas.

Cooling CreamPro CreamPro Roll-On

Frequently Asked Questions

Full Spectrum CBD: Professional FAQ

The most common questions practitioners ask about full spectrum formulations, the entourage effect, and how Kannaco products compare.